tag:blogger.com,1999:blog-2318756985870843725.post8630495967347898933..comments2024-03-21T03:36:00.644-04:00Comments on Caroline's Breast Cancer Blog: Hurry up already!Carolinehttp://www.blogger.com/profile/14607559482363983911noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-2318756985870843725.post-68147864050712668892010-04-15T09:48:23.579-04:002010-04-15T09:48:23.579-04:00I haven't read every blog you've written, ...I haven't read every blog you've written, but I know enough to know you have a chance to meet your maker a head of time. My two best friends have breast cancer. One is in remission and the other has stage IV and desires not to spend the years she has left with chemo drugs pumping through her veins. I'll have to say to anyone, I cannot begin to imagine, nor do I pretend to understand the fear of a cancer victim. I wish you well and will keep you in my thoughts and prayers.<br /><br />Lorri<br /><br />PS Good luck with the new job!Lorri's Web Design, Inchttps://www.blogger.com/profile/12297891343535212241noreply@blogger.comtag:blogger.com,1999:blog-2318756985870843725.post-91744981896609154052010-04-07T05:14:08.139-04:002010-04-07T05:14:08.139-04:00More than 70 clinical, epidemiological and basic s...More than 70 clinical, epidemiological and basic studies, accessible in databases, confirm the remarkable anticancer properties of antidepressants. <br /><br />Julian Lieb, M.D<br />127 Cumberland Road<br />Burlington<br />Vermont 05408<br /><br /><br />CANCER DEFEATED <br />Prostaglandins are infinitesimal, ephemeral and powerful molecules regulating the chemistry of every cell in the body, including cells regulating mood, and those regulating immune function. When produced within normal limits, prostaglandins regulate the chemistry of every cell; when produced excessively, physiology becomes pathology. When brain cells produce excessive concentrations of prostaglandins, they depress mood and immunity. In 1973, David Horrobin showed that antidepressants inhibit prostaglandins, and in 1977 that prostaglandins regulate nucleic acids (DNA and RNA).1,2 Others subsequently showed that prostaglandins regulate the synthesis, inhibition, and expression of genes, and the growth, differentiation, and replication of cells, with cancer the accelerated replication of abnormal cells.1,2 Excessive synthesis of prostaglandins induces cancer, with genes determining the variations. In 1998, Brenda Penninx showed that at age 70, chronically depressed people have an increased risk of 88% of developing cancer, and 50% of dying of it. <br />More than seventy clinical, laboratory, and epidemiological studies have shown that antidepressants kill cancer cells, inhibit their proliferation, convert multidrug resistant cells to chemotherapy sensitive, augment chemotherapy, protect nonmalignant cells from damage by radiation and chemotherapy toxicity, and target the mitochondria of cancer cells while sparing those of healthy ones.1,2 Antidepressants have therapeutic potential in many cancers that are often treatment resistant, such as gliomas, cancers of the lung, kidney, liver, and uterus, inflammatory breast cancer, and multiple myelomas.2 Antidepressants are capable of arresting lung cancer in advanced stages, and even reversing it. That antidepressants are effective for a multitude of malignancies, decries the myth that cancer is a hundred diseases, when it is one disease with a hundred variations. <br />Antidepressants alleviate cancer pain, alone or combined with narcotics, remit nausea and vomiting, promote sleep, relieve anxiety and depression, and combat fatigue. Other inhibitors of prostaglandins, such as COX-1 and COX-2 inhibitors, also have potential value in defeating cancer. The components are in place for a revolution in cancer prevention and treatment, as may be confirmed by accessing “Medline” or “Pubmed,” and entering “antidepressants” and “cancer.” <br />The history of medicine is littered with the suppression of innovation. Today many cancer organizations rely on the opinions of medical advisors, some of whom are political operatives of vested interests disguised as healers. It is not for a lack of innovation that we are in our predicament, but the suppression of it. In “Against Method” Paul Feyerabend wrote that suppressing a paradigm in preference to one politically favored could permanently damage society, and that resistance to progress could be so intractable that political intervention might be needed. <br />1. Lieb, J.”The multifaceted value of antidepressants in cancer therapeutics.” Eur J Cancer. Editorial Comment. (2008) 172-174<br />2 Lieb,J.”Defeating cancer with antidepressants.”ecancermedicalscience”DOI. 10.3332/eCMS.2008.88<br />3. Lieb, J “Killing Cancer.” (1010) Amazon (in press).<br />I am a semi-retired, former Yale medical school professor, and author of 48 articles and 11 books. You may Google me if you wish.<br />For educational purposes only. Treatment decisions must be made with a physician.Anonymousnoreply@blogger.com